Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS‐2. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. ![]() Hospitalization in rural regions was also associated with aspirin underuse.ĭespite improvements in early use of aspirin for AMI in China, there remains marked variation in practice and opportunities for improvement that are concentrated in some hospitals and patient groups.Ĭ Unique identifier: NCT01624883.Īcute myocardial infarction aspirin quality of care. Treatment was less likely in patients who were older, presented with cardiogenic shock at admission, presented without chest discomfort, had a final diagnosis of non-ST-segment elevation acute myocardial infarction, or did not receive reperfusion therapy. However, about 15% of hospitals had a rate of use of <80% in 2011. Using data from the China Patient-centered Evaluative Assessment of Cardiac Events Retrospective Study of Acute Myocardial Infarction (China PEACE-Retrospective AMI Study), we identified a cohort of 14 041 patients with AMI eligible for early aspirin therapy. ![]() However, the rates and recent trends of aspirin use for the early treatment of AMI in China are unknown. ![]() JAMA.Aspirin is an effective, safe, and inexpensive early treatment of acute myocardial infarction (AMI) with few barriers to administration, even in countries with limited healthcare resources. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The miracl study: A randomized controlled trial. Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D,et al. Vale N, Nordmann AJ, Schwartz GG, de Lemos J, Colivicchi F, den Hartog F,et al. Comparison of Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Discharged on Versus Not on Statin Therapy (from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Trial). Larsen AI, Tomey MI, Mehran R, Nilsen DWT, Kirtane AJ,Witzenbichler B,et al. Patients using statin treatment within 24 h after admission for ST-elevation acute coronary syndromes had lower mortality than non-users: a report from the first Euro Heart Survey on acute coronary syndromes.Eur Heart J. Lenderink T, Boersma E, Gitt AK, Zeymer U, Wallentin L, Van de Werf F,et al. Toward a healthy and harmonious life in china: Stemming the rising tide of non-communicable diseases2011.Available. However, half of patients still did not receive intensive statin therapy in 2011.Given that guidelines strongly endorse intensive statin therapy for acute myocardial infarction patients, initiatives promoting the use of statin therapy, with attention to treatment intensity, would support further improvements in practice. The use of statin therapy has dramatically increased over the past decade in Chinese patients with acute myocardial infarction. Patients without low-density lipoprotein cholesterol measured were less likely to be treated with statin or to receive intensive therapy. Among treated patients, those receiving intensive statin therapy increased from 1.0% in 2001 to 24.2% in 2006 to 57.2% in 2011(P<0.001 for trend). Regional variation in statin use correspondingly decreased over time. Statin use among hospitalized patients with acute myocardial infarction increased from 27.9% in 2001 to 72.5% in 2006, and 88.8% in 2011 (P<0.001 for trend). Using a nationally representative sample of patients with acute myocardial infarction admitted to 162 Chinese hospitals in 2001, 20, we identified 14,958 patients eligible for statin therapy to determine rates of statin use and the intensity of statin therapy, defined as those statin regimens with expected low-density lipoprotein cholesterol lowering of at least 40%, to identify factors associated with the use of statin therapy. The use of statin, and the intensity of their use, has not been described in acute myocardial infarction patients in China, a country with a rapidly growing burden of cardiovascular disease. Statin therapy is among the most effective treatments to improve short- and long-term mortality after acute myocardial infarction.
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